Abstract
BackgroundBioactive components from medicinal plants are said to be responsible for the antioxidant and antimicrobial effects of plant extracts. It was the main purpose of this paper to evaluate the total phenolic content (TPC), total flavonoid content (TFC), and antioxidant and antimicrobial activities of leaf extracts of Euclea schimperi.ResultsStrong evidence was found when a positive correlation was found between TPC or TFC and antioxidant power. To put it differently, TPC of the E. schimperi leaf extracts varied between 748.78 ± 3.11 mgGAE/100 g of dry extract (methanol) and 40.45 ± 0.66 mgGAE/100 g of dry extract (chloroform) while TFC varied from 3.306 ± 0.142 mgQE/100 g of dry extract (methanol) to 0.334 ± 0.002 mgQE/100 g dry extract (chloroform). Similarly, all extracts exhibited significant amount of antioxidant and antimicrobial activities. Ferric reducing power was ranged between 312.145 ± 1.542 mgAAE/100 g extract (methanol) and 48.177 ± 0.286 mgAAE/100 g (chloroform). DPPH radical scavenging activity (%) lied between 83.4% (methanol) and 58.5% (chloroform). The voltammetric analysis of the crude extract gave three different sharp peaks at the oxidation potential side. Finally, the reducing agent capacity of the extracts was further confirmed by synthesizing silver nanoparticles from AgNO3 solution and the plant crude extracts. Crude extracts of E. schimperi leaves showed various degree of antimicrobial activity towards different standard strains with mean zone of inhibition ranging from 0 to 20.67 mm. Both solvent leaf extracts of E. schimperi exhibited MIC ranging from 62.5 to 125 mg/mL towards most bacterial species.ConclusionsEuclea schimperi leaf extracts were found to contain high amount of total phenolic and small amount of flavonoid compounds which play a major role in controlling oxidation. In general, therefore, the results prove the effectiveness of the plant for its excellent antioxidant and antimicrobial activities. Accordingly, the positive values of the plant in traditional medicines have been confirmed.
Highlights
Traditional medicine is regarded as a combination of knowledge, skill and practice originated from theories, experiences and attitudes native to various cultures that is utilized to treat and diagnose enormous types of physical and mental complications and maintain health [1]
Many people in the world rely on traditional medicine
Phytochemical screening tests The preliminary phytochemical tests are helpful in finding information about chemical constituents present in the plant material [22]
Summary
Traditional medicine is regarded as a combination of knowledge, skill and practice originated from theories, experiences and attitudes native to various cultures that is utilized to treat and diagnose enormous types of physical and mental complications and maintain health [1]. Since in the early stage, plants have been used as a source of medicinal compounds and still continued to play a major role in the human health [3]. They are the Mekonnen et al Chem. Bioactive components from medicinal plants are said to be responsible for the antioxidant and antimicrobial effects of plant extracts. It was the main purpose of this paper to evaluate the total phenolic content (TPC), total flavonoid content (TFC), and antioxidant and antimicrobial activities of leaf extracts of Euclea schimperi
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