Investigation of antifungal and antioxidant properties of Capparis ovata methanolic extracts

Hamit Uslu,Gözde Ati̇la,Kemal Meti̇ner,Oktay Ozkan,Baran Çeli̇k,Dinçer Erdağ,Fatma Esi̇n Kirik,Asım Kart

doi:10.24998/maeusabed.460081

Abstract

Caper plant belonging to the genus Capparis (family Capparaceae) is a plant used in traditional medicine to cure various illnesses since ancient times. Studies have shown significant medicinal properties of various Capparis species. This study was designed to examine in vitro antifungal and antioxidant activity of methanolic extracts of Capparis ovata buds. It was determined that Capparis ovata inhibited the NO radical in a dose-dependent manner and exhibited reducing power activity. According to the standard pyrocatechol graph, 1 mg of Capparis ovata contains 19.64 µg of phenolic equivalent of pyrocatechol. In vitro antifungal susceptibilty testing of Capparis ovata methanolic extract against eight different fungal strains were determined by broth macrodilution method. According to MIC values of in vitro antifungal activity testing Capparis ovata has moderate antifungal activity. In conclusion, Capparis ovata was found to have a significant antifungal and antioxidant potential. Hence, this plant could have the potential to be used against fungal and oxidative stress related many disease conditions.

Highlights

The caper plant is locally called with different names as bubu, gebere, gabar, kapari, keper and kebere in Turkey
In Vitro Antifungal Susceptibility Testing: Reference methods were used according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI) for in vitro antifungal
The C. ovata methanolic extract at different amounts was compared with Rutin standard for Nitric oxide (NO) radical scavenging activity (Figure 1)

Summary

Introduction

The caper plant is locally called with different names as bubu, gebere, gabar, kapari, keper and kebere in Turkey It is generally consumed as pickles due to economical and nutritional. Properties (Duman and Ozcan, 2014; Belviranlı et al, 2016) This plant belongs to the family of Capparaceae and to the genus Capparis with 250 and 400 species. They are grown generally in tropical and subtropical regions but some are in temperate regions in the Mediterranean including Turkey (Lansky et al, 2013). It is aimed to investigate the antioxidant and antifungal activities of C. ovata species in this study

Preparation of Plant Material and Extracts

Antifungal Activity Testing

NO Radical Scavenging Activity

Results

Discussion considering in therapeutic formulations to cure