Abstract
Aim of the experiment: The present study was designed to investigate the anti-arthritic potential of the plant Hibiscus hispidissimus. Materials and Methods: The aerial parts of the plant was collected, dried and extracted (maceration) with ethanol. Preliminary phytochemical studies were carried out. All the in-vitro models i.e. inhibition of protein denaturation, membrane stabilization and proteinase inhibition were carried out with standard reference drug diclofenac sodium. Result: Dose dependent and significant (p<0.05) anti arthritic activity in in-vitro models were found. Conclusion: The results reveal promising anti arthritic potential of the plant. However further pharmacological investigation using isolated active ingredients can be carried out to confirm its efficacy and mechanism of action.
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