Abstract
The angiogenesis process is an essential issue in tissue engineering. Zinc oxide nanorods are biocompatible metals capable of generating reactive oxygen species (ROS) that respond to induced angiogenesis through various mechanisms; however, released Zn (II) ions suppress the angiogenesis process. In this study, we fabricated green ZnO nanorods using albumin eggshell as a bio-template and investigate its angiogenic potential through chorioallantoic membrane assay and excision wound healing assay. This study demonstrated that angiogenesis and wound healing processes depend on pro-angiogenic factors as VEGF expression due to ZnO nanorods' exiting. Angiogenesis induced via zinc oxide nanorods may develop sophisticated materials to apply in the wound healing field.
Highlights
Neovascularization is considered as an essential issue in regenerative medicine and tissue engineering (Ennett and Mooney, 2002)
The result supported that the appearance of hydroxo, oxo, or aqua species on the surface of zinc oxide nanorods was due to the existence of excess oxygen content in the nanomaterial (Silverstein and Bassler, 1962; Farmer, 1974)
The results indicated the high quality of Zinc oxide (ZnO) nanorods
Summary
Neovascularization is considered as an essential issue in regenerative medicine and tissue engineering (Ennett and Mooney, 2002). This issue has occurred via the microvascular process (Rouwkema et al, 2008). Angiogenesis depends on factors like VEGF (Petrova et al, 1999), FGF (Ma, 2000), and angiopoietin activators of integrins (Suri et al, 1996). VEGF is an excellent, effective regulator to induce the angiogenesis process, there are enormous challenges to applying tissue engineering. The presence of the material induces cells to produce VEGF, and FGF as a growth factor may help overcome these challenges. Previous studies reported that ROS functionalized in wound healing and cell proliferation throughout the activation of growth factors (Sen et al, 2002; Roy et al, 2006; Huo et al, 2009)
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