Abstract
Convergent OCD neuroimaging studies demonstrate symptom-associated striatal hyperactivity resolved by effective treatment. However, the roles of spiny projection neuron (SPN) subtypes in compulsive behavior are unclear. Here we dissected contributions of D1- and D2-SPNs using a model system that displays hyperactivity in central striatum (CS) and OCD-relevant behaviors: Sapap3-KO mice.
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