Abstract
2-aminoethyldiphenyl borate (2-APB) elicits both potentiation and inhibition effect on Ca2+ influx via CRAC channels. In this study we focused on understanding the underlying mechanism of its potentiation effect. We identified one key residue which are just located in the pore region, plays a vital role in the potentiating effect caused by 2-APB. Mutation of this residue with small side chain such as C, A, G, completely eliminate the potentiating effect, while mutation with large side chain such as M and I could generate 2-APB induced potentiation current as WT. Our results imply that the potentiation effect caused by 2-APB might has a close relationship with the change in the pore diameter.
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