Investigating the interaction of terbinafine with xanthenes dye for its feasible determination applying the resonance Rayleigh scattering technique.

Mohamed A Abdel-Lateef,Deena A M Nour El-Deen,Sayed M Derayea,Mohamed Oraby,Albandary Almahri

doi:10.1098/rsos.201545

Abstract

Terbinafine hydrochloride is a potent antifungal drug indicated for oral and topical treatment of mycoses. A resonance Rayleigh scattering (RRS) method was developed for the determination of terbinafine hydrochloride through a feasible complexation reaction with erythrosine B. In a weakly acidic medium (acetate buffer, pH 5.0), terbinafine hydrochloride can react with erythrosine B through the electrostatic attraction and virtue of hydrophobic force to form an ion-association complex. The reaction resulted in the appearance of a new RRS peak at 369 nm. The RRS peak was increased by increasing the concentration of terbinafine hydrochloride in the linear range of 0.1–1.5 µg ml−1. All the reaction conditions (erythrosine B concentration, buffer volume, diluting solvent and pH) were optimized. The detection limit was 0.029 µg ml−1 while the quantitation limit was 0.089 µg ml−1. The suggested method after its validation was successfully applied for the determination of terbinafine hydrochloride in different pharmaceutical formulations (tablets and cream) with sufficient recovery.

Highlights

The last decades have seen unmatched alterations in the fungal infections pattern in individuals [1]
Terbinafine is applied for the treatment of cutaneous candidiasis, dermatophytoses, pityriasis versicolor and superficial fungal infections like onychomycosis, seborrheic dermatitis and tinea capatis because of its short-duration therapy [4,5]
The resonance Rayleigh scattering (RRS) spectrum of terbinafine−erythrosine B system is shown in figure 2

Summary

Introduction

The last decades have seen unmatched alterations in the fungal infections pattern in individuals [1]. These fungal diseases have undertaken considerable importance owing to their rising incidence in patients with acquired immune deficiency syndrome disease, in recipients of solid organ transplants, in persons with malignancies diseases and in other immune-compromised individuals [1]. Terbinafine hydrochloride is an allylamine derivative (figure 1) that has a powerful antifungal activity through inhibition of the squalene epoxidase enzyme in fungal cell wall synthesis [3]. Terbinafine is applied for the treatment of cutaneous candidiasis, dermatophytoses, pityriasis versicolor and superficial fungal infections like onychomycosis, seborrheic dermatitis and tinea capatis because of its short-duration therapy [4,5]. Excessive terbinafine may produce some undesirable side effects like allergic reactions (swelling of tongue and face, difficulty in breathing and throat closing), skin rash, blood problems and changes in vision [4]

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