Abstract
Compositional asymmetry is a characteristic of the plasma membrane whose biological importance is still mostly unknown. Asymmetric model membranes mimicking cell membrane composition offer a useful, highly controlled system for studying the coupling between lateral and transverse lipid organization. We have explored the influence of the low-melting (low-TM) lipid in a ternary mixture on macroscopic domain formation in asymmetric giant unilamellar vesicles (aGUVs). Symmetric GUVs composed of DPPC/low-TM lipid/Chol (39/39/22 mol%) with varied low-TM chain length (14:1-PC, 16:1-PC, 18:1-PC, 20:1-PC, and 22:1-PC) were prepared by electroformation.
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