Abstract
Aim: Studying in rabbit model, the bone behavior during the process of osseointegration of dental implants mimicking vitamin deficiency D3.Materials and Methods: Six rabbits received implants in the area of the removed lower first incisor after creating a condition of vitamin D3 deficiency. Afterwards, the examinations were carried out on days 3, 5, 7, 30, and 90 when all animals were removed from the experiment. At that time, a bone block was collected within the installed dental implant, with the intact area and the area of the adjacent tooth. The samples were examined by histomorphometry analysis.Results: In rabbits with vitamin D3 deficiency, dental implants could be osseointegrated by the regeneration of the bone tissues after surgeries. However, a decrease in the number of cells involved in the construction of bone tissue—osteocytes—was recorded in the regenerated bone (40% ± 7%) as compared with the native bone immediately after implantation, before the bone remodeling processes.Conclusions: The study’s results on the rabbit model in vivo confirmed the relationship between vitamin D3 and the process of osseointegration. This in vivo experiment can be the basis for future clinical study.
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