Abstract
This study was founded for the purpose investigate the differences in effects of combined medication of pioglitazone and melbine and single-use of pioglitazone on the levels of hba1c, blood fat and insulin sensitivity of elder patients with type II diabetes mellitus (T2DM), to provide clinical reference and guidance for the treatment of T2DM in elder patients. For this purpose, we selected a total of 120 elder patients with T2DM who visited the clinic or were admitted to this hospital between July 2016 and July 2017 and divided them into the observation group and the control group (n=60 for each group). For the control group, they only took pioglitazone for treatment, while those in the observation additionally took melbine for treatment. Then, we observed the levels of FPG, 2hPG, HbA1c, blood fat, FINS, 2hINS and HOMA-IR. Results showed that after treatment, significant decreases were seen in levels of FPG, 2hPG and HbA1c in patients of two groups compared to the levels before treatment, and the levels in the observation group decreased more evidently than those in the control group (p<0.05); besides, the levels of total glyceride, total cholesterol and LDL-C were all significantly lower than those before treatment, with an elevated HDL-C, and those levels of TG, TC and LDL-C in the observation group were significantly lower than those in the control group; the level of HDL-C was higher than the control group (p<0.05). Similar decreases were identified in the levels of FINS, 2hFINS and HOMA-IR after treatment (p<0.05), and the levels in the observation group were also significantly lower than those in the control group (p<0.05). In the observation group, the incidence rate of adverse reactions was 10% (6/60), while in the control group was 8.33% (5/60), but the difference between the two groups showed no statistical significance (p>0.05). It is concluded that combined medication of pioglitazone and melbine can effectively reduce the levels of plasma glucose, blood fat and the HOMA-IR, with an elevated sensitivity to insulin, but no severe adverse reactions, manifesting a promising safety in long-term administration. It is worthy of being promoted in clinical practice.
Highlights
Diabetes mellitus (DM), the third chronic noninfectious disease only secondary to the malignancies and cardiovascular diseases, has become an emergent public health issue facing the world [1]
Blood fat An automatic biochemical analyzer was utilized to measure the level of blood fat, oxidase endpoint method to measure the levels of total cholesterol (TC) and triglyceride (TG), and immunoturbidimetry to measure the levels of high-density lipoprotein cholesterol (HDL-C) and low-density-lipoprotein cholesterol (LDL-C)
DM refers to a group of diseases caused by disorders in the metabolism of carbon hydrate, fat and proteins, mainly manifested by the chronic increase in plasma glucose, and has been regarded as a kind of chronic disease requiring lifelong treatment . [12] A study has indicated that DM is one of high-risk factor contributing to the cardio- or cerebrovascular diseases, and poor control of plasma glucose, without any intervention, results in complications in vessels, eyes, feet or nerve system, or even severe condition threatening the physical health and life quality of patients [13]
Summary
Diabetes mellitus (DM), the third chronic noninfectious disease only secondary to the malignancies and cardiovascular diseases, has become an emergent public health issue facing the world [1]. With the rapid development in life quality and the changes in life style, a rapid increase has been witnessed in the population of DM: Currently, there have been 250 million DM patients in the world, and according to the estimate of International Diabetes Federation, this digit will surpass 330 million by the year of 2025. In China, people are suffering from DM: In 2016, the population of DM patients has increased to more than 30 million, and simultaneously, China is facing the tremendous burden posed by the treatment of DM, as well as its complications [2]. The acute increase in the elder population contributes to the rapid growth of T2DM patients, which has been regarded as a rigorous social problem. Research has shown effective management of plasma glucose, so as to maintain the plasma glucose at an ideal level, has become the major method in the prophylaxis of the T2DM and reducing its complications in elder patients [4]
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