Abstract
The current study aimed at assessing the association between neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) for the prognosis of the surgical outcome of epithelial ovarian cancer (EOC). EOC patient medical records of surgical operations between January, 2005 and December, 2015 were reviewed and their data of clinicopathological complete blood counts (CBCs) and surgical outcomes were collected. To assess their effects on surgical outcomes, PLR and NLR optimal predictive values were determined and then compared with each other. A statistically significant relation was found between surgical outcomes and NLR and PLR (p<0.001 and p<0.001), for which new cutoff points were gained (PLR: 192,3,293; NLR: 3). The sensitivity and specificity were 0.74 and 0.67, respectively for PLR and 0.74 and 0.58, for NLR. NLR and PLR seem to be useful methods for the prediction of surgical outcomes in patients with EOCs. Increased NLR and PLR proved to be beneficial for poor surgical outcomes. Moreover, PLR increase showed further help in the predicting outcome of EOC suboptimal debulking.
Highlights
From among gynecologic cancers, epithelial ovarian cancer (EOC) is the major cause of mortalities in the United States, accounting for 3.6% of all types of gynecologic cancers (3rd rank) throughout the world (Jemal et al, 2010), while less than 40% of woman afflicted with ovarian cancer are treated (Siegel et al, 2015)
The current study aimed at assessing the association between neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) for the prognosis of the surgical outcome of epithelial ovarian cancer (EOC)
A statistically significant relation was found between surgical outcomes and NLR and PLR (p
Summary
Epithelial ovarian cancer (EOC) is the major cause of mortalities in the United States, accounting for 3.6% of all types of gynecologic cancers (3rd rank) throughout the world (Jemal et al, 2010), while less than 40% of woman afflicted with ovarian cancer are treated (Siegel et al, 2015). A major reason for this poor treatment is that most EOC patients are frequently involved in an advanced stage of the disease. Other characteristics such as, race, age, histologic type, grade, tumor marker, and residual tumor after surgery are required to be identified as prognostic factors (Fathalla, 1972; Vergote et al, 1993; Kodama et al, 1997). NLR enhancement of epithelial ovarian cancers was discovered to correlate with adverse clinical outcomes (Kokcu et al, 2014; Yildirim et al, 2014). An investigation on EOC (Asher et al, 2011) was even indicative of the better diagnostic
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