Abstract
Pharmaceutical solids can often form solvated species which can affect the material’s physical and chemical stability. Carbamazepine (CBZ) has been proven to form a 1:1 solvate with acetone. This report investigates the solvation behavior of CBZ over a wide temperature and acetone concentration range using Dynamic gravimetric Vapor Sorption (DVS). The solvation transition point increased from 62.5% P/P0 at 10°C to 97.8% P/P0 at 30°C, resulting in a 15.9 kJ mol−1 heat of solvation. The desolvation kinetics were studied between 15 and 30°C, indicating CBZ desolvation is a first-order reaction with autocatalysis by the desolvated product and an activation energy of 81.9 kJ mol−1.
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