Abstract
ABSTRACT: Pressure injury they are chronic wounds where the is bacterial infection common and represent a challenging problem for public health. The aim of this study was investigating the antimicrobial activity of Mangifera indica on bacteria associated by pressure injury. In vitro tests were conducted with crude extract and fractions organics against strains Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Staphylococcus saprophyticus (ATCC 15305) e Escherichia coli (ATCC 25922) through in agar-well diffusion assay and the minimal inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. The extracts ethanolic was the most active, with diameter of inhibition zones ranging between 19,0 and 22,0 mm against the tested bacterial strains. The CIM varied from 0,04 and 0,29 mg/ml against all the tested microorganism also to the extract ethanolic. The fractions organics hexanic and methanolic showed antimicrobial activity against all the tested microorganisms. Chemical study to extraction and isolation of active compound is recommended to in vitro assays these compounds to investigate the antimicrobial activity. KEYWORDS: Mangifera indica. Pressure injury. Antimicrobial activity.
Highlights
A partir do metabolismo secundário das plantas, são produzidas substâncias Página | 3197 como alcaloides, flavonoides, terpenos, compostos fenólicos, entre outras, as quais constantemente têm suas propriedades farmacológicas e medicinais, tais como: antimicrobiana, anti-inflamatória, cicatrizante, antitumoral, antiparasitária e antioxidante; comprovadas (RAFIEIAN-KOPAEI, 2012)
The aim of this study was investigating the antimicrobial activity of Mangifera indica on bacteria associated by pressure injury
In vitro tests were conducted with crude extract and fractions organics against strains Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Staphylococcus saprophyticus (ATCC 15305) e Escherichia coli (ATCC 25922) through in agar-well diffusion assay and the minimal inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined
Summary
Volume 6, Número 3 (jul./set. 2021) pp: 3196-3208. https://periodicos.ifal.edu.br/diversitas_journal/ © Diversitas Journal. O objetivo deste estudo foi investigar a atividade antimicrobiana de Mangifera indica em bactérias associadas a lesão por pressão. Os testes in vitro foram realizados com extrato bruto e frações orgânicas contra cepas de Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Staphylococcus saprophyticus (ATCC 15305) e Escherichia coli (ATCC 25922) por meio de ensaio de difusão em ágar com poço. O extrato etanólico foi o mais ativo, com diâmetro das zonas de inibição variando entre 19,0 e 22,0 mm contra as cepas bacterianas testadas. A CIM variou de 0,04 e 0,29 mg/ml contra todos do microrganismo testado. As frações orgânicas hexânica e metanólica mostrou atividade antimicrobiana contra todos do microrganismo testado. Estudo químico para a extração e o isolamento de compostos ativos é recomendado para realização de ensaios in vitro destes compostos para investigar a atividade antimicrobiana.
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