Abstract
SUMMARY In 14 cases, simultaneous clearances of inulin (range 39 to 160 ml. per minute) and endogenous creatinine were measured, and in 11 of these cases, the results were compared with the simultaneous clearance of radioactive (57Co) vitamin B12. The clearance of free (dialysable) 57Co vitamin B12 correlates closely with inulin clearance (ρ=0·985), and can be used as a measure of glomerular filtration rate. [Clearance of vitamin B12 (free)=1·07 clearance of inulin—10·9±5·48 (2 S.D.). ] The protein bound (non‐dialysable) fraction of the plasma 57Co vitamin B12 varied from patient to patient, and in the same patient at different times (range, 9·6% to 35·7%; mean, 17·7% of total), in spite of presaturation with stable vitamin B12. Because of this, the clearance of vitamin B12 is a valid measure of glomerular filtration rate only when correction is made for plasma protein binding as measured in the individual subject. The correlation between inulin and endogenous creatinine clearance was less precise. [Ratio of clearance of creatinine to clearance inulin=1·20±0·38 (2 S.D.).]
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