Abstract
Interest of carbohydrate deficient transferrin in alcoholic patients admitted for alcohol detoxification. We evaluate the use of carbohydrate-deficient transferrin (CDT) assay among alcoholic patients (16 women aged 34 to 66 years and 42 men aged 28 to 68 years, median values 45 years for both sexes) hospitalized for alcohol detoxification. CDT (using the Tinaquant Roche reactive on a Hitachi 917), γGT and mean corpuscular volume (MCV) were measured at admission (d1) and after 10 days of abstinence (d10). At admission, the sensitivity of the CDT (65.5 %) is significantly different that of γGT (82.8 %) and that of the MCV (37.9 %). Mean CDT value at d1 is significatively smaller for women. No links were found between CDT and γGT, at d1, and clinical information on drinking behaviour. 12 % of the patients were positive for the CDT at d1 and negative for γGT. No correlation between CDT and γGT at d1 were found. CDT and γGT could be considered as complementary markers. After 10 days of alcohol abstinence we observe a significant reduction in the rates of the CDT as well as for γGT (p < 10 −4). Mean value of CDT is 8.0 % at d1 and 5.9 % at d10. In conclusion, this study suggests that CDT is useful, complementary, with γGT assay for detecting heavy drinking. Furthermore, CDT could be useful in monitoring patients after alcohol detoxification and for detection of relapses.
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