Abstract
The treatment of rheumatoid arthritis (RA) has progressed considerably since 1897, when aspirin (acetylsalicylic acid) was first synthesized in its pure form by Felix Hoffman, a chemist at Friedrich Bayer & Company in Germany. At that time, the diagnosis of what is now known as RA was based primarily on the presence of four signs and symptoms—dolor (pain), tumor (swelling), rubor (redness over areas of inflammation), and calor (warmth over areas of inflammation). With its beneficial effects on these signs and symptoms, and its ability to reduce fever, aspirin was quickly accepted as a useful drug for the treatment of RA and a broad range of other conditions that involve pain, inflammation, and fever. Initially introduced as a powder, aspirin was quickly, and frequently, counterfeited, prompting Bayer to reformulate it as a tablet in the early 1900s. Thus, aspirin became one of the first pharmaceutical preparations to be commercially produced in tablet form. Ironically, the dosage of the first tablet formulation was 325 mg, the same dosage that is commonly used today.
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