The clinical and metabolic effects of progesterone and anhydrohydroxyprogesterone in rheumatoid arthritis.

Abstract

Article1 May 1950THE CLINICAL AND METABOLIC EFFECTS OF PROGESTERONE AND ANHYDROHYDROXY-PROGESTERONE IN RHEUMATOID ARTHRITISLAURENCE H. KYLE, M.D., DARRELL C. CRAIN, M.D., F.A.C.P.LAURENCE H. KYLE, M.D.Search for more papers by this author, DARRELL C. CRAIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-5-878 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite Hench's observation in 19331that improvement of the joint symptoms in rheumatoid arthritis commonly followed the occurrence of jaundice, practical application of this information met with but meager success.2, 3, 4Five years later, Hench added the significant observation that temporary remission of symptoms occurred frequently during pregnancy.5Until recently, this information, although repeatedly confirmed and thoroughly discussed, did little to advance the therapy of rheumatoid arthritis. Barsi6claimed effectiveness for transfusions of blood of pregnant women but it is the consensus at the present time that this form of therapy has little value.7Although a temporary remission of...Bibliography1. 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AbelsDobriner JCK: Effect of progesterone on the nitrogen balance and on the circulating proteins of a normal man. Conference on Metabolic Aspects of Convalescence, Jos. Macy Jr. Found. 7: 121, 1944. Google Scholar20. AlbrightReifenstein FEC: The parathyroid glands and metabolic bone disease, 1948, The Williams & Wilkins Co., Baltimore, Md. Google Scholar21. Reich NE: The use of large doses of progesterone in rheumatoid arthritis, Am. Practitioner 4: 1-5, 1949. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication November 18, 1949.From the Medical Service, Georgetown University Hospital and the Department of Medicine, Georgetown University School of Medicine.This study was aided in part by the William Wade Hinshaw Cancer Research Grant.We would like to express our gratitude to a number of the assistant medical residents who helped in this study, including Drs. Timothy F. O'Donovan, Clifton Gruver, August Bakos, Thomas O'Brien and John Stapleton. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWirkungen der Gestagene auf den StoffwechselRheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatmentRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.THE REVERSIBILITY OF CERTAIN RHEUMATIC AND NONRHEUMATIC CONDITIONS BY THE USE OF CORTISONE OR OF THE PITUITARY ADRENOCORTICOTROPIC HORMONE*PHILIP S. HENCH, M.D., F.A.C.P.The Modern Treatment of Rheumatoid Arthritis 1 May 1950Volume 32, Issue 5Page: 878-888KeywordsBlood transfusionGratitudeHospital medicineMedical servicesPregnancyProgesteroneResearch grantsRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 May 1950 PDF downloadLoading ...