Introduction of an Efficient Protocol for the Synthesis of Some of the Pyrimidine Derivatives under Solvent-Free Conditions

Abstract

Various pyrimidine derivatives were synthesized via one-pot three-component condensation of aromatic aldehydes, malononitrile, and multiple amines using 1,1'-(butane-1,4-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) hydroxide as a basic ionic liquid catalyst under solvent-free conditions. The advantages of this method are the simplicity of the procedure, short reaction times, high yields, no-column chromatographic separation, commercial availability of the preliminary materials, and reusability of the catalyst.