Introducing a novel therapeutic supplement for osteoporosis: Remedial, cytotoxicity and antioxidant effects of plant extract green-formulated gold nanoparticles

Abstract

Osteoporosis means a decrease in bone density, as a result of which bone strength decreases and becomes brittle, which increases the probability of fracture. Osteoporosis usually develops gradually and does not show any symptoms until a fracture occurs. Osteoporosis can occur in any bone of the body, but it is usually seen in the spine, pelvis, wrists, and ribs. Both men and women at any age may be affected by this disease, but according to statistics, the percentage of women suffering from osteoporosis is higher than men, and the probability of this disease increases with age. Recently, the metallic nanoparticles containing plant extracts have been used for the treatment of bone disorders such as osteoporosis. The obtained nanoparticle (Gold nanoparticles green-formulated by Glycine max L seed extract) was characterized by advanced chemical and physical techniques like TEM, FTIR, and SEM. The cytotoxicity effects of gold nanoparticles against normal cell line i.e. HUVEC were assessed. Administration of gold nanoparticles ‎following methyl prednisolone sodium succinate induced osteoporosis in Wistar rats indicated a raise in the bone mineral content markers serum levels and a reduction in bone resorption markers urinary and serum levels. An incline in tibia and femur strength was observed particularly with 5 µg/kg of gold nanoparticles‎. Calcium homeostasis maintenance, collagen formation and free radicals scavenging can plausibly be the gold nanoparticles action mode ‎thereby combating osteoporosis induced by glucocorticoids.