Abstract
Objectives: To present the effect of intravitreal ranibizumab (IVR) therapy combined with sulfotanshinone sodium (SS) injection in a patient suffering from type II optic disc vasculitis (ODV). Methods: A 26-year-old female patient was diagnosed with type II ODV with macular edema (ME). The information was obtained by complete medical and ophthalmic history taking and a detailed ophthalmic examination at the initial and follow-up visits. Functional and morphological outcomes at baseline, 1 week and 1 month following IVR+SS injections, are presented. Results: Best-corrected visual acuity (BCVA) improved from 78 letters (ETDRS) at baseline to 90 letters at 1-week follow-up and maintained stable through 1-month follow-up. Central retinal thickness (CRT) measured by optical coherence tomography (OCT) decreased from 465 μm at baseline to 240 μm at 1-week follow-up and to 226 μm at 1-month follow-up. Mean deviation (MD) measured by perimetry increased from ?5.17 dB to ?4.59 dB and to ?4.29 dB, respectively. Fluorescein angiography (FFA) showed that the initial macular edema at baseline disappeared while the arm-retina circulation time (ART) was also greatly shortened when compared to the baseline. Electroretinogram (ERG) measured at 1-month follow-up demonstrated an overall improvement of the retinal function after the injection. No ocular or systemic side effects were detected. Conclusions: IVR+SS injection may lead to resolution of the associated ME and improve the retina morphologically as well as functionally. To our knowledge, this is the first case of a type II ODV benefiting from treatment with IVR+SS injection. The observed results warrant further investigation.
Highlights
Optic disc vasculitis (ODV) is an uncommon, chronic and self-limiting disorder characterized by unilateral optic disc swelling and minimal visual symptoms, seen mostly in young adults with no gender predilection [1] [2]
To present the effect of intravitreal ranibizumab (IVR) therapy combined with sulfotanshinone sodium (SS) injection in a patient suffering from type II optic disc vasculitis (ODV)
Mean deviation (MD) measured by perimetry increased from −5.17 dB to −4.59 dB and to −4.29 dB, respectively
Summary
Optic disc vasculitis (ODV) is an uncommon, chronic and self-limiting disorder characterized by unilateral optic disc swelling and minimal visual symptoms, seen mostly in young adults with no gender predilection [1] [2]. Type II ODV is considered to result from phlebitis of the central retinal venous in the region of the optic nerve head or retro-laminar region and is usually misdiagnosed as central retinal venous occlusion (CRVO) because they share quite similar clinical pictures. This 26-year-old female patient presented with obvious ME, exudation and hemorrhage with no big improvement after hormone therapy. Our previous studies have demonstrated the therapeutic effect of SS injections in treating RVO patients [6] [7] [8]. This case study was designed to assess the efficacy and safety of IVR+SS infection in treating this type II ODV patient
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