Abstract
Intravitreal administration of membrane-permeable analogs of cGMP and cAMP markedly enhanced serotonin N-acetyltransferase (NAT) activity in retinas of light-exposed chicks. The effects of cGMP analogs were usually weaker than the actions of cAMP analogs, however, they were more pronounced than the effects of non-cyclic derivative of GMP (i.e., 8-bromo-GMP). Combined treatment with dibutyryl-derivatives of cGMP and cAMP yielded NAT values that were similar to the values produced by the compounds administered separately, whereas NAT activity in chicks receiving a combination of db-cGMP and aminophylline was higher than the enzyme activity produced by the drugs individually. Neither db-cGMP nor aminophylline affected hydroxyindole- O-methyltransferase (HIOMT) activity in retinas of light-exposed chicks. It is hypothesized that cGMP analogs enhance the retinal NAT activity indirectly, via cAMP.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
