Abstract
The anti-inflammatory cytokine Interleukin-10 (IL-10) is efficacious in delaying delivery, reducing fetal wastage, and increasing birth weight, independent of gestational age when administered to pregnant rats experimentally infected with Escherichia coli. Radiolabeled IL-10 rapidly crosses the rat placenta, suggesting that maternal infusion of IL-10 may dampen the fetal immune response. This study was designed to evaluate characteristics of transplacental passage of IL-10 in the pregnant ewe, with intent to replicate the established preterm labor rat model in a larger animal.
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