Abstract
Background and objectivesThe pathophysiological mechanism of sarcopenia in the elderly has not yet been fully understood. Here, we aim to explore the relationship between sarcopenia and the inflammatory cytokine interleukin-6 (IL-6), and the anti-inflammatory cytokine interleukin-10 (IL-10) in an elderly population.MethodsOur study comprised 118 males and 46 females aged between 61 and 90 who had received a general medical examination in Tianjin First Central Hospital. Subjects were divided into a sarcopenia group and a non-sarcopenia group, defined according to the criteria of the Asian Working Group for Sarcopenia (AWGS). We compared body composition, handgrip strength (HS), gait speed (GS), biochemical indexes, levels of IL-6 and IL-10, living habits, and disease status between these groups.ResultsNon-sarcopenia subjects undertook more regular physical exercise than sarcopenia patients. Sarcopenia subjects had higher nutrition risk but lower body mass index (BMI), serum albumin (ALB), triglyceride (TG), and creatinine (Cr) levels compared to non-sarcopenia subjects. Sarcopenia subjects were older and had higher visceral fat tissue (VFA) than non-sarcopenia subjects (P < 0.05), along with higher IL-6 and IL-10 levels. Furthermore, IL-6/IL-10 ratios were higher in subjects with sarcopenia (P < 0.05). Age, BMI, levels of physical activity, nutritional risk, VFA, IL-6, IL-10, IL-6/IL-10 ratio were independently associated with the presence of sarcopenia in univariate regression analyses. Following adjustment for confounding factors, the presence of sarcopenia was positively correlated with IL-6, IL-10, IL-6/IL-10 ratio and inversely correlated with BMI. Age is associated with increased presence of sarcopenia.ConclusionsThe levels of inflammation cytokine IL-6, anti-inflammatory IL-10 and IL-6/IL-10 ratio were increased in elderly sarcopenia subjects. Sarcopenia was associated with increased levels of inflammatory cytokine IL-6, anti-inflammatory cytokine IL-10, and IL-6/IL-10 ratios.
Highlights
Background and objectivesThe pathophysiological mechanism of sarcopenia in the elderly has not yet been fully understood
Rong et al BMC Geriatrics (2018) 18:308 causes and interactions. It may include an ageassociated state of low-degree systemic inflammation [2, 3] - inflammaging, which is characterised by increasing levels of pro-inflammatory cytokines, and decreasing levels of anti-inflammatory cytokines such as interleukin 10 (IL-10) [3]
In the Asian Working Group for Sarcopenia (AWGS) criteria for sarcopenia in older people [6], diagnosis is based on presentation of criterion 1, plus either criterion 2 or criterion 3 with recommended cutoff values for muscle mass measurements (7.0 kg/m2 for men and 5.7 kg/m2 for women based on bioimpedance analysis), handgrip strength-HS (< 26 kg for men and < 18 kg for women), and usual gait speed-GS (< 0.8 m/s)
Summary
Background and objectivesThe pathophysiological mechanism of sarcopenia in the elderly has not yet been fully understood. Rong et al BMC Geriatrics (2018) 18:308 causes and interactions It may include an ageassociated state of low-degree systemic inflammation [2, 3] - inflammaging, which is characterised by increasing levels of pro-inflammatory cytokines (including tumor necrosis factor alpha-TNFα and interleukin 6 - IL-6), and decreasing levels of anti-inflammatory cytokines such as interleukin 10 (IL-10) [3]. To the best of our knowledge, no studies have yet evaluated the potential role of IL-10 in sarcopenia patients. To investigate this question, we measured serum concentrations of the inflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10, and estimated the association between IL-6 levels, IL-10 levels, and IL-6/IL-10 ratios with sarcopenia in elderly individuals
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
