Abstract
To present and discuss the rationale for using high-dose intravenous human immunoglobulins in the treatment of severe drug eruptions and the clinical results of recently published series. In toxic epidermal necrolysis, intravenous human immunoglobulins were expected to inhibit the apoptosis of epidermal cells by blocking the Fas/Fas ligand pathway. Some controversies persist both on the role of Fas/Fas ligand pathway and on the anti-apoptotic effect of human immunoglobulins in vitro. The clinical results of the treatment of toxic epidermal necrolysis with intravenous immunoglobulins are also controversial, the important differences between series being difficult to explain. More evidence is needed before high-dose intravenous human immunoglobulins can be considered as standard therapy of toxic epidermal necrolysis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Current opinion in allergy and clinical immunology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
