Intrauterine insemination versus timed intercourse in ovulation induction cycles with clomiphene citrate for polycystic ovary syndrome: A retrospective cohort study

Abstract

AimThe aim of this study is to evaluate the effect of intrauterine insemination (IUI) on clinical pregnancy rates in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction (OI) cycles. MethodsWe evaluated the medical records of one hundered and forty-seven infertil anovulatory women with PCOS who attended to the infertility outpatiens clinics of the current hospital. All women underwent either IUI or timed intercourse (TIC) following OI with clomiphene citrate (CC) according to their requests. Some demographic and clinical features, baseline hormone levels and treatment cycle characteristics were recorded for each woman. ResultsOf a total 147 cycles, 56 cycles were with IUI and 91 others with TIC. The IUI and TIC groups were similar in terms of age, BMI, gravidity numbers, parity numbers, number of abortion and infertility duration (p>0.05). There were also no significant differences in hormone parameters (p>0.05). Moreover, no significant difference was observed between the groups regarding semen parameters and weekly coit frequency. However, a significant difference was found in clinical pregnancy rates between the IUI group (48.2%) and the TIC group (11%) (p<0.001). ConclusionCompared to TIC, IUI increases clinical pregnancy rates in infertile women with PCOS who underwent OI with CC.