Intrathecal administration of the adenosine A 1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain

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Effects of intrathecally (i.t.) administered R-phenylisopropyl adenosine (R-PIA), an adenosine A 1 receptor agonist, on presumed pain behaviour were assessed in a rat model of chronic central pain. Spinal cord injury was induced photochemically via laser irradiation of the spinal cord after intravenous injection of erythrosin B in rats. The chronic allodynia-like behaviour that developed in some animals was studied. R-PIA (3 and 10 nmol), injected i.t. reduced the mechanical and cold allodynia-like symptoms as tested with von Frey filaments and ethyl-chloride spray, respectively. No side effects were observed. The effect of R-PIA was significant for up to 5 h and was reversed by theophylline, an adenosine receptor antagonist.