Abstract
Intraperitoneal injection is a kind of simple and convenient to drug of style in order to verify intraperitoneal injection adenovirusPmultirnai-ldhcThe plateau pika (Ochotona curzoniae (Ochotona curzoniac) Skeletal MuscleLdhcGene Silence of feasibility will27Only plateau pika (Ochotona curzoniae) divided into interference group, Shell Group and blank control group each group9Only individual interference group and Shell Group respectively Injection0.65 mLAdenovirusPmultirnai-ldhcAnd adenovirusPmultirnai-NSBlank control group injected with the same amount of physiological saline injection after7/dDetection Skeletal Muscle inLdhcGeneMRNAAnd protein of Expression Level Determination the lactate dehydrogenase (LDH) Activity and lactic acid (LD) And three phosphoric acid adenosine (ATP) Of content. Results show that and blank control group compared interference group inMRNAAND PROTEIN LEVEL,LdhcGene expression respectively reduce41.73%And15.76%; Lactate dehydrogenase (LDH) Activity, lactic acid (LD) AndATPContent respectively reduce23.98%,51.08%And19.29%. Results (intraperitoneal injection adenovirusPmultirnai-ldhcCan effective silence Skeletal Muscle inLdhcGene expression.
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