Antihyperglycaemic, antioxidative activities of a formulated polyherbal drug MTEC (Modified) in streptozotocin-induced diabetic rat.

Abstract

Musa paradisiaca belongs to the family of Musaceae and is distributed throughout India and Malaysia. The plant has medicinal value as antidiabetic agent. Seeds of Tamarindus indica of Caesalpiniaceae family used as traditional medicine for the management of diabetes mellitus found throughout India. Eugenia jambolana an evergreen tree of Myrtaceae family is used as traditional medicine for the management of diabetes in India. Coccinia indica of Cucurbitaceae family is distributed widely all over India and its medicinal value as antidiabetic agent is well recognized. The diabetic therapeutic efficacy of a formulated polyherbal drug (abbreviated form MTEC), constituted with n-hexane fractions of the hydromethanol extract of root of M. paradisiaca, seed of T. indica, seed of E. jambolana and leaf of C. indica at specific ratio was investigated in streptozotocin-induced diabetic rats. Streptozotocin-induced diabetic state was confirmed here by the monitoring of increased level of fasting blood glucose, decreased glycogen level in liver and skeletal muscle along with elevation in the activities of glucose-6phosphatase and lactate dehydrogenase and diminution in the activities of hexokinase as well as glucose-6-phosphate dehydrogenase in liver, skeletal muscle and cardiac muscle. Oral administration of MTEC (modified) at a dose of 100 mg/5 ml of olive oil/Kg body weight daily to the diabetic rats significantly (P<0.05) corrected fasting blood glucose level, glycogen contents of liver and skeletal muscle along with said carbohydrate metabolic enzyme activities in liver, skeletal and cardiac muscles in diabetic rat towards the control levels. Diabetes mellitus induced oxidative stress was also corrected significantly (P<0.05) by the treatment of this polyherbal drug (modified MTEC) to the diabetic rat. Results of the present study support the therapeutic potentiality of this polyherbal drug MTEC for the management of diabetes.