Abstract
ObjectiveTo determine whether intraperitoneal silymarin administration has favorable effects on the heart, lungs, kidney, and liver and on oxidative stress in a rat model of supraceliac aorta ischemia/reperfusion injury.MethodsThirty male Wistar albino rats were divided equally into three groups: sham, control, and silymarin. The control and silymarin groups underwent supraceliac aortic occlusion for 45 min, followed by a 60 min period of reperfusion under terminal anesthesia. In the silymarin group, silymarin was administered intraperitoneally during ischemia at a dose of 200 mg/kg. Rats were euthanized using terminal anesthesia, and blood was collected from the inferior vena cava for total antioxidant capacity, total oxidative status, and oxidative stress index measurement. Lungs, heart, liver and kidney tissues were histologically examined.ResultsIschemia/reperfusion injury significantly increased histopathological damage as well as the total oxidative status and oxidative stress index levels in the blood samples. The silymarin group incurred significantly lesser damage to the lungs, liver and kidneys than the control group, while no differences were observed in the myocardium. Furthermore, the silymarin group had significantly lower total oxidative status and oxidative stress index levels than the control group.ConclusionIntraperitoneal administration of silymarin reduces oxidative stress and protects the liver, kidney, and lungs from acute supraceliac abdominal aorta ischemia/reperfusion injury in the rat model.
Highlights
Acute supraceliac abdominal aorta ischemia may occur during treatment for abdominal aortic aneurysms, dissection repair of acute thromboembolism with aortic atherosclerosis, or trauma surgery
total antioxidant capacity (TAC) activity was higher in blood samples from the silymarin group than in samples from the sham and control groups (P0.05) (Table 1, Figure 1)
The scores for kidney, lungs and liver were significantly higher in the control group than in the sham and silymarin groups (P
Summary
Acute supraceliac abdominal aorta ischemia may occur during treatment for abdominal aortic aneurysms, dissection repair of acute thromboembolism with aortic atherosclerosis, or trauma surgery. In such cases, reactive oxygen species are generated and there is excess production of pro-inflammatory molecules and a subsequent inflammatory response, which can lead to damage to internal organs, such as the lungs, liver, kidneys, intestines and heart, as well as death[1]. Multiple organ dysfunction occurring after abdominal aortic surgery is one of the major causes of mortality and morbidity, This study was carried out at Kahramanmaraş Sütçü Imam University, Faculty of Medicine, Department of Cardiovascular Surgery, Kahramanmaraş, Turkey. Article received on September 2nd, 2016 Article accepted on October 11th, 2016
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