Abstract
OBJECTIVE: Polycystic ovary syndrome, myoma uteri and endometrioma are frequently seen gynecologic problems and all three diseases may cause infertility. Aim of this cross-sectional study was to compare total antioxidant status, ceruloplasmin, total sulfhydryl , total oxidant status, lipid hydroperoxide and oxidative stress index levels in endometrial flushing fluid of patients with Polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19), and healthy women (n=20).STUDY DESIGN: We compare endometrial flushing fluid of patients with polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19) and healthy women (n=20). Endometrial flushing fluid samples were collected during the implantation window of all women.RESULTS: Mean age of groups was 28.90±5.45, 37.25±2.73, 32.84±6.62 and 32.15±5.18 in Polycystic ovary syndrome, myoma uteri, endometrioma and control groups, respectively (p<0.05). Mean total antioxidant status, ceruloplasmin and total sulfhydryl levels indicating antioxidant state were comparable between Polycystic ovary syndrome, myoma uteri, endometrioma and control groups (p=0.806, p=0.156, p=0.328 respectively for markers). Similarly, oxidant state-related markers didn’t differ significantly between 4 groups (p=0.090 for total oxidant status, p=0.087 for lipid hydroperoxide, p=0.312 for oxidative stress index).CONCLUSION: Endometrial flushing fluid total antioxidant status, total oxidant status, lipid hydroperoxide, ceruloplasmin, and total sulfhydryl levels during implantation window didn’t differ between women with Polycystic ovary syndrome, uterine leiomyoma, endometrioma, and healthy controls.
Highlights
Polycystic ovary syndrome (PCOS), myoma uteri and endometrioma are frequently seen gynecologic problems and all three diseases may cause infertility
Ceruloplasmin and total sulfhydryl levels indicating antioxidant state were comparable between Polycystic ovary syndrome, myoma uteri, endometrioma and control groups (p=0.806, p=0.156, p=0.328 respectively for markers)
Mid-luteal phase serum progesterone levels were similar in uterine myoma (9.61), PCOS (9.47) and control groups (8.75), while it was lower in a statistically significantly way in the endometrioma group (6.26; p < 0.01, 0.05, 0.05, respectively). Both average gravida and parity values were lowest in the PCOS group and highest in the control group with a statistically significant difference between groups (Table I)
Summary
Polycystic ovary syndrome (PCOS), myoma uteri and endometrioma are frequently seen gynecologic problems and all three diseases may cause infertility. Impaired endometrial receptivity is common infertility causing factors and may be related to these diseases. Endometrial receptivity might be hampered by abnormal cytokine levels, hormonal signaling, and epigenetic factors. For this reason, a better understanding of endometrial receptivity at the cellular and molecular level and identification of the role implantation markers in this process might help predict pregnancy outcomes and allow the use of assisted reproductive techniques to improve the success rate. Quick Response Code: Access this article online. How to cite this article: Demir M. Oxidative Stress in Endometrial Flushing Fluid of Patients with Polycystic Ovary Syndrome, Endometrioma and Uterine Leiomyoma: Comparison with Healthy Controls.
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