Abstract
Keratoacanthoma is a benign lesion with rapid development and spontaneous healing, similar to well-differentiated squamous cell carcinoma (SCC). Although keratoacanthoma is usually related to sun exposure, other etiologies, such as tobacco, trauma, and immunosuppression, are considered. A 77-year-old white female who was an ex-smoker sought treatment at our stomatology clinic with a chief complain of non-healing aphthae that had first appeared 3 months earlier. Intraoral examination revealed an exophytic nodule with hard borders and a corrugated surface, associated with areas of erythroleukoplakia at the mucosal commissure. Diagnostic hypotheses included SCC, verrucous carcinoma, and hyperplastic chronic candidiasis. Cytopathology indicated candidiasis, and treatment was administered. An incisional biopsy indicated a diagnosis of intraoral keratoacanthoma associated with candidiasis, and complete remission of the lesion was observed after 1 month of treatment. Given that the clinical and histopathological features of keratoacanthoma are very similar to those of SCC, making an accurate diagnosis is very important for devising an appropriate treatment.
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