Abstract
Abstract We have studied the cardiopulmonary hemodynamics of acute hemodilution in a group of patients with cancer. The majority of patients had multisystem disease; including chronic lung disease, liver disease, sepsis, and malnutrition. The only patients who were excluded were those with a recent history of myocardial ischemia. Acute intraoperative hemodilution to a hematocrit of 22% was well tolerated provided blood volume was maintained with crystalloid solution. Hemodilution led to improved cardiac output by enhancing venous return which helped to compensate for the diminished oxygen content of the blood. There were no adverse cardiopulmonary effects in hemodiluted patients compared to patients undergoing similar operations without hemodilution. Acute normovolemic hemodilution is an effective clinical means of reducing the use of bank blood and avoiding the risks of blood transfusion in patients undergoing major surgery.
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