Abstract
Abstract Purpose To review IOL features that affect PCO Methods Review of clinical PCO studies using retroillumination imaging and objective quantification of PCO following cataract surgery and laboratory EM studies of IOL profile Results The optic diameter, haptic design and IOL material all affect PCO performance but the optic edge profile is the most important. Electron microscopy shows IOL edge is of variable profile in so called 'square edge' IOLs and this can be explained by the inevitable interrelationship of the limitations that material imposes on engineering, early closure of the capsular bag around the IOL seems to be important in preventing leakage of LECs into the retro lenticular space soon after surgery that later proliferate and form clinical PCO Conclusion PCO has a multifactorial pathogenesis. Improved IOL design can limit but does not prevent PCO Commercial interest
Published Version
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