Abstract
Intranasal leptin improves survival after opioid overdose in a mouse model
Highlights
More than 120 daily deaths in the United States are attributed to opioid overdose and mortality is accelerating with the intersection between the opioid crisis and the COVID-19 pandemic [1]
We have previously reported that intranasal (IN) leptin prevents opioid induced respiratory depression, the main cause of death related to opioids [3]
We investigate if the intranasal route effectively delivers leptin to the brain, where it acts on respiratory control centers [4–6], and if it prevents opioid-related deaths
Summary
Intranasal leptin improves survival after opioid overdose in a mouse model Carla Freire1,2* , Huy Pho, Shannon Bevans‐Fonti, Luiz U. We have previously reported that intranasal (IN) leptin prevents opioid induced respiratory depression, the main cause of death related to opioids [3]. In this translational study, we investigate if the intranasal route effectively delivers leptin to the brain, where it acts on respiratory control centers [4–6], and if it prevents opioid-related deaths. Mice received IN leptin at 1.2 mg/ kg (n = 26) or IN vehicle (n = 25) followed by intraperitoneal (IP) injection of morphine at 400 mg/kg 30 min after the IN treatment.
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