Abstract

Introduction: While the use of ketamine to treat severe depression and post-traumatic stress disorder has been well documented in the literature, fewer studies have investigated the efficacy of Intramuscular (IM) ketamine to treat these conditions.

Highlights

  • While the use of ketamine to treat severe depression and post-traumatic stress disorder has been well documented in the literature, fewer studies have investigated the efficacy of Intramuscular (IM) ketamine to treat these conditions

  • In order to increase access to ketamine therapy during the COVID-19 pandemic that unfolded in 2020, the centers described in this report joined the Colorado Health First network (CHF)

  • In order to accomplish this, our centers converted from a treatment model based on IV ketamine to one based on IM ketamine. These operational changes resulted in a decrease in costs and an increase in the ability to provide access to psychedelic treatments to a much larger group of patients. In this case series we present our treatment results on a series of forty sequential patients who had a diagnosis of major depressive disorder and who received our new IM protocol

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Summary

Introduction

While the use of ketamine to treat severe depression and post-traumatic stress disorder has been well documented in the literature, fewer studies have investigated the efficacy of Intramuscular (IM) ketamine to treat these conditions. In order to accomplish this, our centers converted from a treatment model based on IV ketamine to one based on IM ketamine These operational changes resulted in a decrease in costs and an increase in the ability to provide access to psychedelic treatments to a much larger group of patients. In this case series we present our treatment results on a series of forty sequential patients who had a diagnosis of major depressive disorder and who received our new IM protocol.

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Results
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