Abstract
Intramucosal-arterial PCO2 gap does reflect tissue dysoxia.
Highlights
Dubin and coworkers [1] subjected anaesthetized, paralyzed sheep to decreases in oxygen delivery either by progressive bleeding (ischaemic hypoxia [IH] group) or by decreasing oxygen saturation (hypoxic hypoxia [HH] group)
In their recent paper, Dubin and coworkers [1] subjected anaesthetized, paralyzed sheep to decreases in oxygen delivery either by progressive bleeding or by decreasing oxygen saturation
This premise, may not be correct because it appears from the data presented that animals in the HH group did not reach an anaerobic state, and were unable to mount increases in ∆PCO2
Summary
Dubin and coworkers [1] subjected anaesthetized, paralyzed sheep to decreases in oxygen delivery either by progressive bleeding (ischaemic hypoxia [IH] group) or by decreasing oxygen saturation (hypoxic hypoxia [HH] group). They found substantial increases in mesenteric venous–arterial blood partial carbon dioxide tension (PCO2) gradient (∆PCO2) in the IH group, whereas ∆PCO2 remained unchanged both in the HH and in a sham operated control group. The fundamental premise of comparable anaerobic states for both groups is based on the presence of oxygen dependence.
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