Abstract
Intraluminal mass-forming preinvasive neoplasms occurring within the gallbladder and the ampulla of Vater are highly analogous to pancreatic or biliary intraductal papillary and tubular neoplasms, as evidenced by their papillary and/or tubular growth, variable cell lineage, and spectrum of dysplastic change (adenoma-carcinoma sequence), often with significant overlap. A uniform terminology of intracholecystic papillary-tubular neoplasm (ICPN) and intra-ampullary papillary-tubular neoplasm (IAPN) has therefore been proposed for the systematic analysis of these neoplasms. ICPN and IAPN are biologically indolent; noninvasive examples show an excellent prognosis, whereas those with invasion exhibit a malignant but nevertheless significantly better prognosis than ordinary invasive carcinomas unaccompanied by ICPN or IAPN.
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