Single center experience in patients with intracholecystic papillary-tubular neoplasm (ICPN)

Abstract

Introduction: Intracholecystic papillary-tubular neoplasm (ICPN) has recently been reported as a new concept in the classification of gallbladder tumors. ICPN is defined as mass-forming preinvasive neoplasm (>1cm) of the gall bladder and shows many similarities to intraductal papillary neoplasm of the bile duct (IPNB) and intraductal papillary mucinous neoplasm (IPMN). We analyzed the cases of ICPN and compared with gall bladder cancer (non-ICPN) in our center. Method: We retrospectively reviewed the medical records of patients who diagnosed ICPN and/or Gall bladder cancer in our center from January 2010 to October 2017. Patient data and clinical outcomes were collected and analyzed. Results: There were 11 patients who diagnosed ICPN and 144 patients who diagnosed gall bladder cancer (non-ICPN) in our center. There was no significant difference in demographics between two groups. Two year survival rate was 83.3% in ICPN group, 73.2% in non-ICPN group. (p=0.11) Among the 11 patients in ICPN group, Three patients diagnosed ICPN with high grade dysplasia, 8 patients diagnosed ICPN with adenocarcinoma (Invasive ICPN). Two patients died due to the disease in ICPN group. Among the two patients, one patient who diagnosed ICPN with high grade dysplasia and multiple BilIN recurred early with peritoneal seeding. Conclusions: ICPN group shows better survival rate than non-ICPN group without statistical significance. Concomitant ICPN and multiple bilIN may suggest a bad prognosis. Continued follow up and research on ICPN should be needed.