Abstract
As measured by X-ray microanalysis of frozen-dried cryosections, physiological concentrations of phosphorus, Na +, K +, and Mg 2+ show a biphasic age dependence in some compartments of rat hepatocytes, especially in the regions of condensed chromatin associated with the actively transcribed genes. This could be consistent with a reactivation of the protein synthesizing apparatus in old livers. The decrease in intracellular water concentrations in hepatocytes and myocytes during ageing is shown to be solely due to a preferential decrease in the water concentration in mitochondria. As a consequence, ionic strength in mitochondria increases with age. This result could provide a rationale for a better understanding of functional declines found in mitochondria from old donors.
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