Abstract

In visual cortex layer II/III pyramidal neurons, long-term depression (LTD) of synaptic currents was induced by a combination of the intracellular increase of inositol-1,4,5-trisphosphate (IP 3), achieved by photolyzing caged-IP 3, and the tetanization to nearby cortex, but not by either of these two procedures alone. A facilitatory role of an IP 3-induced calcium release in LTD is suggested.

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