Abstract
Cells contain one or more of a family of homologous calcium binding proteins which act as transducers for relaying changes in intracellular calcium concentrations to the appropriate target systems. These proteins, of molecular weight 16–20 000, have one or more calcium binding sites which have an affinity for calcium in the micromolar range. Binding of calcium to theses sites causes conformational changes in the proteins which alter their interaction with the target proteins, normally causing activation of the appropriate system. In certain cases, this interaction can be modified by the action of other second messengers, particularly cyclic AMP. In addition, other calcium-binding proteins are known which are of importance in the response to changes in intracellular calcium.
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