Abstract
Clinical case description: A 61-year-old man with severe erectile dysfunction related to diabetes mellitus of long duration was treated through intracavernous stem cell application. Transplantation of autologous bone marrow stem cells through a single intracavernous injection was performed. Clinical response, Doppler ultrasound of the penis, and adverse events were evaluated during the 50-week follow-up. The highest clinical response was reported at week 12, but it diminished thereafter. At the end of follow-up, ultrasound identified the presence of neovascularization emerging from the cavernous arteries.
 Relevance: Numerous preclinical trials have demonstrated efficacy and safety, but there is insufficient clinical evidence showing promising results.
 Clinical implications: No adverse events were detected, and ultrasound revealed hemodynamic changes that were possibly related to the therapy. The source and dosage of stem cells, as well as subsequent therapeutic applications, pose questions that remain to be answered.
 Conclusions: Stem cell therapy for erectile dysfunction is a field of research that has sparked interest in numerous scientific groups, but clinical experience is still limited.
Highlights
Erectile dysfunction (ED) is a condition of considerable prevalence worldwide, affecting 19.2% of the male population.[1]
The inconvenience of those therapeutic modalities lies in the high risk of adverse events, such as local pain and bruising related to continuous prostaglandin analog injections, infections, and complications related to the surgical procedure of penile prosthesis
We present our experience of a patient with medical treatment-refractory ED, who rejected second and third-line therapy, and instead, opted for transfusion with autologous bone marrow total nucleated cells at our hospital
Summary
Erectile dysfunction (ED) is a condition of considerable prevalence worldwide, affecting 19.2% of the male population.[1]. Conclusiones: La terapia con células madre para la disfunción eréctil es un campo que ha despertado el interés de numerosos grupos científicos. Results showed hyperechoic images following the vascular tract, suggestive of atheromatous plaque in both cavernous arteries, with a diameter of 0.09mm (Figure 1).
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