Abstract
Background & Aim Stem cell therapy for erectile dysfunction is a field that has aroused the interest of the scientific society. Numerous preclinical studies have demonstrated the efficacy and safety of this therapeutic modality. However, the clinical experience of stem cells in erectile dysfunction remains very limited. We present a case of severe erectile dysfunction resistant to iPDE5, related to long-term diabetes mellitus treated with intracavernous stem cells. Methods, Results & Conclusion The intervention was intracavernous autologous bone marrow stem cell transplantation, in a single application. A 50-week follow-up was performed, evaluating the therapeutic response by means of several standardized clinical questionnaires, penile doppler ultrasound and the presence of adverse effects. Among the results obtained, we registered a maximum clinical response at week 12 of follow-up, which subsequently decreased progressively. Ultrasonographic findings revealed the presence of neovascularization emerging from the cavernous arteries at the end of follow-up. Although there is still insufficient evidence and standardization of therapeutic protocols, this result encourages future research of SCs as a possible therapeutic modality. Randomized clinical trials should be done in order to respond doubts regarding this procedure.
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