Abstract
Abstract To evaluate the use of tenecteplase in transoperative phacoemulsification in healthy rabbits, the study was carried out with fifteen New Zealand rabbits, divided into three groups: control group (CG), untreated group (UG) and treated group (TG). UG and TG were operated by phacoemulsification and TG received 50 µg / 0.3 mL of intracameral tenecteplase. The postoperative evaluations were 24 h, 72 h, 7 days, 15 days and 21 days. In TP21 the animals were submitted to euthanasia and aqueous humor samples were collected. No significant differences were observed in the clinical evaluations between CG and TG in relation to incidence rates of intraocular pressure (IOP), corneal edema, fibrin deposits, hyphema, aqueous flare and synechia. In the physicochemical evaluation of the aqueous humor, there were no significant differences between the three groups in relation to pH values and concentrations of chloride ions. The aqueous humor density values were statistically different between CG and the other groups. In the histological evaluation, there were no significant differences between the groups. The use of tenecteplase in transoperative phacoemulsification in rabbits did not present significant differences in terms of clinical, physicochemical and histological parameters.
Highlights
Cataracts is one of the main causes of vision loss in humans and domestic animals[1]
Significant differences in intraocular pressure (IOP) between treated group (TG) and untreated group (UG) were not found at any time-point of evaluation
At TP3 and TP7, the IOP returned to the baseline values, while at TP15, the IOP was below the baseline values at TP0 and returned to the normal range at TP21 (Table 2)
Summary
Cataracts is one of the main causes of vision loss in humans and domestic animals[1]. Uveitis stands out among the postoperative complications following PHACO and is due to the immune response to the presence of lenticular proteins in the anterior chamber (AC) and to tissue injury resulting from excessive intraoperative manipulation of the intraocular structures. Disruption of the blood-aqueous barrier (BAB), which might be due to both surgical manipulation and uveitis, results in cell migration and extravasation of proteins from the vascular compartment to the AC, where they promote changes in the composition of the aqueous humor (AH)(3,4). Fibrin deposition in the AH has been observed in the eyes of dogs/humans with anterior uveitis[5,6] and is directly related to the postoperative period following PHACO[5,7]. The presence of fibrin in the AC is a predisposing factor for the occurrence of synechia, pupillary block, secondary glaucoma and blindness[3,4,8]
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