Abstract
The clinical management of the elective midtrimester abortion continues to be unsatisfactory as judged by either national mortality or morbidity rates. This report documents the results of a randomized series of 16 midtrimester abortions induced by either intra-amniotic hyperosmolar urea and 5 mg. of prostaglandin F2α (PGF2α) or intra-amniotic hyperosmolar urea alone. Pertinent clinical characteristics and biochemical determinations were compared between these two groups. A series of 150 patients were then treated with urea and 5 mg. of PGF2α. The clinical results of this series of patients are presented and compared with a previous group who had urea and 10 mg. of PGF2α. These studies demonstrate that 5 mg. of PGF2α with 80 Gm. of urea achieves injection-abortion intervals that are less than 24 hours.
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