Abstract
Purpose: Intra-articular (i.a.) calcium crystal deposition is common in knee osteoarthritis (OA), particularly in end-stage disease. Low-grade inflammation related to crystals may contribute to knee pain, including pain fluctuation. However, results on this matter have been conflicting in prior studies. Detection of chondrocalcinosis has relied on radiographs to date, which have low sensitivity, and this may have limited the ability to adequately assess the relation of chondrocalcinosis to knee pain.
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