Abstract
The two articles in this month’s press of e Journal of Arthritis, one by Ekinci et al. titled ‘A New Treatment Option in Osteoarthritis: Prolotherapy Injections’ and the other by Senatorov et al. titled ‘Clinical Outcome of Hylan G-F 20 Injections in Shoulder and Hip Osteoarthritis: A Retrospective Review’ raise several important points surrounding the topic of intra-articular injections [1,2]. Firstly that there is a paucity of high quality literature in the eld that o en leads to inconclusive or misrepresented conclusions on drug e cacy in established treatments [1,2]. e articles also highlight the heterogeneity in injection procedure, site, concentration, preparation and outcome measurements [1,2]. is editorial will, therefore, provide a concise review on some of the current injection therapies and suggest possible improvements to methodological structure to inspire readers strive for high quality data. Further, through an example of a possible novel therapy, Actovegin, this editorial will hopefully challenge readers’ way of thinking to consider the reapplication of established drugs; posing the question can you teach an old drug new tricks?
Highlights
The two articles in this month’s press of The Journal of Arthritis, one by Ekinci et al titled ‘A New Treatment Option in Osteoarthritis: Prolotherapy Injections’ and the other by Senatorov et al titled ‘Clinical Outcome of Hylan G-F 20 Injections in Shoulder and Hip Osteoarthritis: A Retrospective Review’ raise several important points surrounding the topic of intra-articular injections [1,2]
The Cochrane Musculoskeletal Group 2015 would consider cortical steroid to still be experimental in treating knee OA, they highlight two key issues for injection therapy
Dextrose solutions above 10% act by inducing osmotic rupture of local cells and increase growth factors in the extracellular matrix [1]. This concise review article advocates the safe use of Prolotherapy injections and echoes our thoughts on the limitations of current literature by low power, poor quality study and variation in drug preparations [1]
Summary
The two articles in this month’s press of The Journal of Arthritis, one by Ekinci et al titled ‘A New Treatment Option in Osteoarthritis: Prolotherapy Injections’ and the other by Senatorov et al titled ‘Clinical Outcome of Hylan G-F 20 Injections in Shoulder and Hip Osteoarthritis: A Retrospective Review’ raise several important points surrounding the topic of intra-articular injections [1,2]. This editorial will, provide a concise review on some of the current injection therapies and suggest possible improvements to methodological structure to inspire readers strive for high quality data.
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