Abstract
Suppressive effect of Ginkgo biloba extract (EGb 761) on topsin induced ovarian toxicity and oxidative stress in albino ratsSaber A. Sakr,Hoda A. Mahran, Asmaa M. Abdel-Maksoud
Highlights
Stress is a reaction alongside a perceived threat to physical, mental, emotional and spiritual health, leading to a series of physiological responses and adaptations
The results showed that IP administration of 1 mg/Kg nicotine (IP Nic 1) and intra-accumbal injection of 1 and 5 μg/mouse nicotine (NAc Nic 1 and 5) lead to weight loss
The weight of the adrenal gland was significantly raised in IP Nic groups
Summary
Stress is a reaction alongside a perceived threat (real or imaginary) to physical, mental, emotional and spiritual health, leading to a series of physiological responses and adaptations. Studies have shown that the NAc (a part of the ventral striatum), Plays a vital role in reward, reinforcement and motivational aspects of behaviors toward addiction. This nucleus is involved in reward aspects of the addictive substance, psychological dependence, and withdrawal syndromes. Addictive drugs increase dopamine release in the sNAc. The mesolimbic dopaminergic system plays an important role in controlling the effects of stress. The role of nicotinic receptors in the nucleus accumbens, one of the most important parts of the mesolimbic system in reducing the effects of stress in mice has been studied
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