Abstract
1. 1. The uptake ( J d ) of fatty acids (FA), fatty alcohols (Alc) and cholesterol (C) into the jejunum of rats (R, Rattus norvegiens), rabbits (RAB, Oryctolagus cuniculus), guinea pigs (GB, Curia porcellus). and hamsters (H, Mesocricetus auratus) was assessed in vitro. 2. 2. Using jejunal discs the J d of Alc was H > R = GP > RAB. the J d of FA was H-RAB > R > GP, but the J d of C was R > H > RAB > GP. 3. 3. The J d of FA was quantitatively and qualitatively different when using jejunal biopsies; in man the J d of FA into biopsies was greater than in the other animal species, but there was no difference in J d of FA into normal human jejunal biopsies and those showing severe abnormalities in villus architecture. 4. 4. There are marked species differences in the passive permeability properties of the jejunum and in the effective resistance of the overlying unstirred water layer, but these differences do not explain the species variations in the uptake of cholesterol.
Published Version
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