Abstract
Intestinal permeability studies for piperaquine from dihydroartemisinin—piperaquine antimalarial product in the presence of lamivudine
Highlights
Ex-vivo studies involving stomach and intestinal segments have been extensively reported as a model for assessing the permeation or diffusion of drug molecules across absorptive membranes (Luo et al, 2013)
DP has been recommended by the World Health Organization for the treatment of multi-drug resistant P. falciparum malaria
This study revealed that LMV reduced the intestinal permeability of PQ from DP on co-administration
Summary
Ex-vivo studies involving stomach and intestinal segments have been extensively reported as a model for assessing the permeation or diffusion of drug molecules across absorptive membranes (Luo et al, 2013). This model serves as a preliminary evaluation of oral drug absorption and its mechanisms (Li et al, 2014). Dihydroartemisinin–piperaquine (DP) is a cost-effective and well-prescribed drug for the treatment of uncomplicated Plasmodium falciparum malaria (Mori et al, 2014). DP has been recommended by the World Health Organization for the treatment of multi-drug resistant P. falciparum malaria. Malaria is a life-threatening parasites infection which can co-exist with Human Immunoviral (HIV) infection, thereby requiring the co-
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